Full List of Publications

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  • Peng, C. and Eckhardt, L.A. Role of the Igh intronic enhancer Emu in clonal selection at the pre-B to immature B cell transition. (2013) J. Immunol. 191: 4399-4411. PMCID: PMC3810302
  • Yan Yl, Pieretti, J., Ju, Z., Wei, S. Christin, J., Bah, F., Birshtein, B.K., and Eckhardt, L.A. Homologous elements hs3a and hs3b in the 3’ regulatory region of the murine immunoglobulin heavy chain (Igh) locus are both dispensable for class-switch recombination. (2011) J. Biol. Chem. 286:27123-27131. PMCID: PMC3149305
  • Li, F., Yan, Y., Pieretti, J, Feldman, D.A., and Eckhardt, L.A. (2010) Comparison of identical and functional Igh alleles reveals a nonessential role for Emu in somatic hypermutation and class-switch recombination. J. Immunol. 185:6049-6057. (Epub ahead of print Oct. 11, 2010)
  • Li, F. and Eckhardt, L.A. (2009) A role for the IgH intronic enhancer, Eμ, in enforcing
    allelic exclusion. J Exp Med. 206:153-67. Epub 2008 Dec 29.
  • Yan, Y., Park, S.S., Janz, S., and Eckhardt, L.A. (2007) In a model of immunoglobulin (IGH)/MYC translocation, the Igh 3’ regulatory region induces MYC expression at the immature stage of B cell development. Genes, Chrom. & Cancer 46: 950-959.
  • Zhang, B., Alaie-Petrillo, A., Kon, M., Li, F. and Eckhardt, L.A. (2007) Transcription of a productively rearranged Ig VDJC does not require the presence of HS4 in the Igh 3’ regulatory region. J. Immunol. 178: 6297-6306.
  • Zhou, Jie, Saleque, S., Ermakova, O., Sepulveda, M., Eckhardt, L.A., Schildkraut, C.L., and Birshtein, B.K. (2005) J. Immunol. 175: 2317-2320
  • Garrett, F.E., Emelyanov, A.V. Sepulveda, M.A., Flanagan, P., Volpi, S. Li, F. Loukinov, D., Eckhardt, L.A., Lobanenkov, V.V. and Birshtein, B.K. (2005) Mol. Cell. Biol. 25: 1511-1525
  • Salas, M. and Eckhardt, L.A. (2003) Critical role for the Oct-2/OCA-B partnership in Ig-secreting cells. J. Immunol. 171:6589-6598.
  • Shi, X. and Eckhardt, L.A. (2001) Deletional analyses reveal an essential role for the hs3b/hs4 IgH 3 enhancer pair in an Ig-secreting but not an earlier-stage B cell line. Int. Immunol. 13:1003-1012.
  • Sharif, N., Radomska, H.S., Miller, D.M., and Eckhardt, L.A. (2001) Unique function for carboxyl-terminal domain of Oct-2 in Ig-secreting cells. J. Immunol. 167:4421-4429.
  • Stevens, S., Ong, J., Kim, U., Eckhardt, L.A., and Roeder, R.G. (2000) The Role of OCA-B in 3'IgH Enhancer function. J. Immunol. 164:5306-5312.
  • Hines, M.D., Radomska, H.S. and Eckhardt, L.A. (1998) Transcription factor affects chromosome constitution of hybrid cells. Cytogenetics and Cell Genet. 83:64-72.
  • Ong, J., Stevens, S., Roeder, R.G., and Eckhardt, L.A. (1998) 3'IgH enhancer elements shift synergistic interactions during B cell development. J. Immunol. 160:4896-4903.
  • Arulampalam, V., Eckhardt, L., and Pettersson, S. (1997) Developmental control of immunoglobulin gene expression in B lineage cells. Immunology Today 18:549-554.
  • Choi, J.K., Shen, C-P., Radomska, H.S., Eckhardt, L.A. and Kadesch, T. (1996) E47 activates the Ig-heavy chain and TdT loci in non-B cells. EMBO J. 15: 5014-5012.
  • Lieberson, R., Ong, J., Shi, X. and Eckhardt, L.A. (1995) Immunoglobulin gene transcription ceases upon deletion of a distant enhancer. EMBO J. 14:6229-6238.
  • Radomska, H.S. and Eckhardt, L.A. (1995) Mammalian cell fusion in an electroporation device. J. Immunol. Methods 188: 209-217.
  • Radomska, H.S., Hines, M.D., and Eckhardt, L.A. (1995) Role of Oct-2 in immunoglobulin gene silencing. In “Gene Expression in Development and Disease,” Annals of N.Y. Acad. Sci. 764: 148-150.
  • Radomska, H.S., Shen, C-P., Kadesch, T., and Eckhardt, L.A. (1994) Constitutively expressed Oct-2 prevents immunoglobulin gene silencing in myeloma x T cell hybrids. Immunity 1:623-634.
  • Lieberman, S., Hines, M., Bergsagel, P.L., Kuehl, M. and Eckhardt, L.A. (1993) Coordinate silencing of myeloma-specific genes in myeloma x T lymphoma hybrids. J. Immunol. 151: 2588-2600.
  • Shen, L., Lieberman, S., and Eckhardt, L.A. (1993) The octamer/?E4 region of the immunoglobulin heavy-chain enhancer mediates gene repression in myeloma x T lymphoma hybrids. Mol. Cell. Biol. 13: 3530-3540.
  • Bergsagel, P.L., Timblin, C.R., Eckhardt, L., Laskov, R., and Kuehl, M. (1992) Sequence and expression of a murine cDNA encoding PC326, a novel gene expressed in plasmacytomas but not normal plasma cells. Oncogene 7: 2059-2064.
  • Eckhardt, L.A. (1992) Immunoglobulin gene expression only in the right cells at the right time. FASEB J. 6: 2553-2560.
  • Lieberson, R., Giannini, S.L., Birshtein, B.K., and Eckhardt, L.A. (1991) An enhancer at the 3' end of the mouse immunoglobulin heavy chain locus. Nucleic Acids Res. 19: 933-937.
  • Porton, B., Zaller, D.M., Lieberson, R. and Eckhardt, L.A. (1990) Immunoglobulin heavy chain enhancer is required to maintain transfected ?2a gene expression in a pre-B cell line. Mol. Cell. Biol. 10:1076-1083.
  • Yu, H., Porton, B., Shen, L., and Eckhardt, L.A. (1989) Role of the octamer motif in hybrid cell extinction of immunoglobulin gene expression; extinction is dominant in a two enhancer system. Cell 58: 441-448.
  • Bikoff, E.K. and Eckhardt, L.A. (1989) Presentation of IgG2a antigens to class II-restricted T cells by stably transfected B lymphoma cells. Eur. J. Immunol. 19:1903-1909.
  • Zaller, D.M., Yu, H. and Eckhardt, L.A. (1988) Genes activated in the presence of an immunoglobulin enhancer or promoter are negatively regulated by a T-lymphoma line. Mol. Cell. Biol. 8: 1932-1939.
  • Bikoff, E., Yu, H., and Eckhardt, L.A. (1988) T cell recognition of endogenous IgG2a expressed in B lymphoma cells. Eur. J. Immunol. 18: 341-348.
  • Yu, H. and Eckhardt, L.A. (1986) DNA rearrangement causes a high rate of spontaneous mutation at the immunoglobulin heavy-chain locus of a mouse myeloma cell line. Mol. Cell. Biol. 6: 4228-4235.
  • Zaller, D.M. and Eckhardt, L.A. (1985) Deletion of a B-Cell specific enhancer affects transfected, but not endogenous, immunoglobulin heavy chain gene expression. Proc. Natl. Acad. Sci. 82: 5088-5092.
  • Eckhardt, L.A. and Birshtein, B.K. (1985). Analysis of independent immunoglobulin class-switch events occurring in a single myeloma cell line. Mol. Cell Biol. 5: 856-868.
  • Marcu, K.B., Yang, J-q., Stanton, L.W., Mushinski, J.F., Fahrlander, P., Eckhardt, L.A. and Birshtein, B.K. (1985). Activation of the c-myc oncogene in murine plasmacytomas. Progress in Cancer Research and Therapy 32: 11-27.
  • Calza, R.E., Eckhardt, L.A., Del Giudice, T., and Schildkraut, C.L. (1984). Changes in gene position are accompanied by a change in time of replication. Cell 36: 689-696.
  • Marcu, K.B., Stanton, L.W., Harris, L.J., Watt, R., Yang, J-q, Eckhardt, L.A., Birshtein, B.K., Remmers, E., Greenberg, R., and Fahrlander, P. (1984) Rearrangement and activation of c-myc oncogene by chromosome translocation in B cell neoplasms. Genetic Engineering 6: 91-116.
  • Stanton, L.W., Yang, J-q., Eckhardt, L.A., Harris, L.J., Birshtein, B.K., and Marcu, K.B. (1984). Products of a reciprocal chromosome translocation involving the c-myc gene in a murine plasmacytoma. Proc. Natl. Acad. Sci. U.S.A. 81: 829-833.
  • Tilley, S.A., Eckhardt, L.A., Marcu, K.B., and Birshtein, B.K. (1983). Hybrid ?2b-?2a genes expressed in myeloma variants: evidence for homologous recombination. Proc. Natl. Acad. Sci. U.S.A. 80: 6967-6971.
  • Eckhardt, L.A., Tilley, S.A., Lang, R.B., Marcu, K.B. and Birshtein, B.K. (1982). DNA rearrangements in MPC 11 immunoglobulin heavy chain class switch variants. Proc. Natl. Acad. Sci. U.S.A. 79: 3006-3010.
  • Kenter, A.L., Eckhardt, L.A., Tilley, S.A. and Birshtein, B.K. (1981). The role of generalized recombination in the heavy chain class switch. ICN-UCLA Symposium of Molecular and Cellular Biology, Volume XX, eds. Janeway, C., Sercarz, E.C., Wigzell, H. and Fox, C.F. pp. 271-280. Academic Press, New York, N.Y.
  • Micklem, H.S., Ledbetter, J.A., Eckhardt, L.A. and Herzenberg, L.A. (1980). Analysis of lymphocyte subpopulations with monoclonal antibodies to Thy-1, Lyt-1, Lyt-2 and ThB antigens. Proceedings of the Columbia College of Physicians and Surgeons Biomedical Symposium on Regulatory Tlymphocytes. Eds. Pernis, B. and Vogel, H.J. pp. 119-132, Academic Press, New York, N.Y.
  • Eckhardt, L.A. and Herzenberg, L.A. (1980). Monoclonal Antibodies to ThB detect close linkage of ly-6 and a gene regulating ThB expression. Immunogenetics 11: 275-291.


Last Updated ( Friday, 21 November 2014 13:45 )