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Research Interest:

  • Molecular Genetics of Lymphocyte Development and Differentiation
    The long-range research goal of this laboratory is to understand the genetic events that accompany lymphocyte differentiation and that specify lymphocyte function. B and T lymphocytes are central to the adaptive immune system - the mechanism by which vertebrates develop long-term and specific immunity to pathogens. B lymphocytes use antibodies to recognize pathogens and give rise to plasmacytes that actively secrete antibodies as a means to eliminate disease-causing organisms.

    The current major research interest of the laboratory is the control of antibody (or immunoglobulin) gene expression in the developing B lymphocyte. We and others have identified multiple transcriptional enhancers within the immunoglobulin heavy chain (IgH) locus. IgH gene assembly, transcription, heavy chain class-switching, and even the malignant transformation of the Ig-secreting cell likely depend upon the action of one or more of these enhancers. We are undertaking functional analyses of the enhancers (using transgenic mice and Igh locus-modified mice) to identify their respective roles in the complex regulation of this immunologically important locus.

Last Updated ( Wednesday, 17 March 2010 13:58 )